Tuesday, January 31, 2012

Democrats defend Obama administration over bungled gun sting (Reuters)

WASHINGTON (Reuters) ? Democrats in the U.S. House of Representatives on Tuesday sought to blunt political attacks on the Obama administration over a botched gun sting operation, saying that the idea of allowing weapons to go across the border to Mexico came from field agents and prosecutors.

Democrats on the House Oversight Committee issued a report just two days before Republicans on the same panel plan to grill Attorney General Eric Holder about the most recent operation, dubbed "Fast and Furious," in which as many as 2,000 guns may have been trafficked to Mexican drug cartels.

President Barack Obama's fellow Democrats said in the 89-page report that the operations and strategies dated back to the Bush administration and were the brainchild of field agents and prosecutors, not officials at the upper levels of government.

"Unfortunately this strategy failed to include sufficient operational controls to stop these dangerous weapons from getting into the hands of violent criminals, creating a danger to public safety on both sides of the border," Representative Elijah Cummings, the senior Democrat on the committee, said in a letter accompanying the 89-page report.

The panel chairman, Republican Darrell Issa, sent a letter to Holder on Tuesday accusing him of engaging in a cover-up and complaining that the Justice Department will not turn over more documents including those about its response to the scandal.

"If the department continues to obstruct the congressional inquiry by not providing documents and information, this committee will have no alternative but to move forward with proceedings to hold you in contempt of Congress," Issa said.

A Justice Department official said the agency was cooperating with the committee and would continue to do so. The agency has turned over several thousand pages to the committee and allowed some senior officials to be interviewed.

Two guns from the Fast and Furious operation were found at the scene where a U.S. Border Patrol agent, Brian Terry, was killed during a shootout with illegal immigrants. It was not clear, however, if those weapons fired the fatal shots.

That operation ran from late 2009 to early 2011 out of the Phoenix offices of the Bureau of Alcohol, Tobacco, Firearms and Explosives and the U.S. Attorney. The goal was to try to track guns being smuggled from the initial purchaser to senior drug cartel members.

However, in most cases ATF agents did not follow the guns beyond the initial buyer. Republicans have questioned who in the administration knew about and approved the operation and its tactics and when. They have issued subpoenas for documents and for witnesses to testify.

Mexican authorities have complained about the flood of weapons coming into their country from the United States and contributing to the deadly war with the drug cartels.

OFFICIALS SAY THEY DID NOT KNOW

The Obama administration has admitted that the operation and its tactics were unacceptable, but senior Justice Department and ATF officials have denied that they knew of the specific tactics until early 2011 - after it was over.

Republicans have expressed doubts about those assertions and some have demanded Holder's resignation as well as that of his senior aide, Assistant Attorney General Lanny Breuer, who runs the Justice Department's criminal division.

"Contrary to repeated claims by some, the committee has obtained no evidence that Operation Fast and Furious was a politically-motivated operation conceived and directed by high-level Obama Administration political appointees at the Department of Justice," Cummings said.

The report said that during "Fast and Furious", agents first sought to bring charges for smaller cases involving the gun buyers, known as straw purchasers, but that senior prosecutors wanted to wait to see if they could bring bigger cases.

It also revealed that authorities in the United States and Mexico had recovered 567 weapons from the botched operation as of January 2011, almost two-thirds of which were found in the United States.

(Editing by Mohammad Zargham)

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/nm/20120131/pl_nm/us_usa_mexico_guns

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Pentagon prepares for new military talks with Iraq

FILE - In this March 16, 2011 file photo, Defense Undersecretary Michele Flournoy testifies on Capitol Hill in Washington. The Obama administration is preparing to begin talks with Iraq on defining a long-term defense relationship that may include expanded U.S. training help, according to Defense Secretary Leon Panetta?s chief policy aide. Flournoy, who is leaving her Pentagon post to return to private life, said in an interview with a small group of reporters that the administration is open to Iraqi suggestions about the scope and depth of defense ties. "One of the things we?re looking forward to doing is sitting down with the Iraqis in the coming month or two to start thinking about how they want to work with" the U.S. military to develop a program of exercises, training and other forms of security cooperation, Flournoy said. (AP Photo/Cliff Owen, File)

FILE - In this March 16, 2011 file photo, Defense Undersecretary Michele Flournoy testifies on Capitol Hill in Washington. The Obama administration is preparing to begin talks with Iraq on defining a long-term defense relationship that may include expanded U.S. training help, according to Defense Secretary Leon Panetta?s chief policy aide. Flournoy, who is leaving her Pentagon post to return to private life, said in an interview with a small group of reporters that the administration is open to Iraqi suggestions about the scope and depth of defense ties. "One of the things we?re looking forward to doing is sitting down with the Iraqis in the coming month or two to start thinking about how they want to work with" the U.S. military to develop a program of exercises, training and other forms of security cooperation, Flournoy said. (AP Photo/Cliff Owen, File)

(AP) ? The Obama administration is preparing to begin talks with Iraq on defining a long-term defense relationship that may include expanded U.S. training help, according to Defense Secretary Leon Panetta's chief policy aide.

Michele Flournoy, who is leaving her Pentagon post on Friday to return to private life, said in an interview with a small group of reporters that the administration is open to Iraqi suggestions about the scope and depth of defense ties.

"One of the things we're looking forward to doing is sitting down with the Iraqis in the coming month or two to start thinking about how they want to work with" the U.S. military to develop a program of exercises, training and other forms of security cooperation, Flournoy said.

The U.S. military completed its withdrawal from Iraq in December after nearly nine years of war. Both sides had considered keeping at least several thousand U.S. troops there to provide comprehensive field training for Iraqi security forces, but they failed to strike a deal before the expiration of a 2008 agreement that required all American troops to leave.

As a result, training is limited to a group of American service members and contractors in Baghdad who will help Iraqis learn to operate newly acquired weapons systems. They are part of the Office of Security Cooperation, based in the U.S. Embassy in Baghdad and headed by Army Lt. Gen. Robert Caslen.

Additional and more comprehensive training is a major issue because Iraq's army and police are mainly equipped and trained to counter an internal insurgency, rather than deter and defend against external threats. Iraq, for example, currently cannot defend its own air sovereignty. It is buying ? but has not yet received ? U.S.-made F-16 fighter jets.

In a new report on conditions in Iraq, a U.S. government watchdog agency said the Iraqi army is giving so much attention to fighting the insurgents that it has had too little time to train for conventional combat.

"The Iraqi army, while capable of conducting counterterrorism and counterinsurgency operations, possesses limited ability to defend the nation against foreign threats," said the report submitted to Congress Monday by the Special Inspector General for Iraq Reconstruction, Stuart W. Bowen, Jr.

In an introductory note, Bowen wrote that while Iraq's young democracy is buoyed by increasing oil production, it "remains imperiled by roiling ethno-sectarian tensions and their consequent security threats."

Iraq has seen an upswing in violence since the last U.S. troop left, but senior U.S. officials have remained in touch in hopes of nudging the Iraqis toward a political accommodation that can avert a slide into civil war.

Vice President Joe Biden spoke by phone on Saturday with Osama Nujaifi, speaker of the Council of Representatives. And Biden spoke on Friday with a key opposition figure, Ayad Allawi, a former interim prime minister and a secular Shiite leader of the Iraqiya political bloc. Allawi has said Iraq needs to replace its prime minister, Nouri al-Maliki, or hold new elections to prevent the country from fracturing along sectarian lines.

In a positive sign, Iraq's Sunni leaders announced on Sunday that they will end their boycott of parliament. That may have paved the way for the political leadership to hold a national conference led by President Jalal Talabani to seek reconciliation and to end a sectarian political crisis.

George Little, the Pentagon press secretary, said Sunday that Panetta remains optimistic about the outlook in Iraq despite worsening violence.

"The secretary believes that the Iraqi people have a genuine opportunity to create a future of greater security for themselves, and that senseless acts of violence will not deter them from pursuing that goal," Little said. "The United States remains committed to a strong security relationship with Iraq."

U.S. officials have said they aim to establish broad defense ties to Iraq, similar to American relationships with other nations in the Gulf, including Saudi Arabia, Kuwait, the United Arab Emirates, Qatar, Oman and Bahrain.

Flournoy, 51, is stepping down from her position as undersecretary of defense for policy on Friday after three years in the job. She is the first woman to hold that post. Her chief deputy, Jim Miller, has been picked to succeed her.

In the interview last week, Flournoy reiterated that she is leaving government to focus more on her family. She and her husband, W. Scott Gould, have three children aged 14, 12 and nine.

She came to the Pentagon in February 2009 from the Center for a New American Security, where she was the think tank's first president. She had served in the Pentagon in the 1990s as a strategist.

Flournoy said in an Associated Press interview in December when she announced her decision to quit that she intends to play an informal role this year in supporting President Barack Obama's re-election effort. She was a member of his transition team after the November 2008 election.

___

Robert Burns can be reached on Twitter at http://www.twitter.com/robertburnsAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-01-30-US-Iraq/id-d8b8bacb808240c995737b5b76d6023a

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Monday, January 30, 2012

Belichick, Brady in cheerful mood at arrival (AP)

INDIANAPOLIS ? Even the usually dour Bill Belichick was joking around as the New England Patriots arrived in Indianapolis for Super Bowl week.

At his opening news conference Sunday night, Belichick was asked if he expected some Hoosier hospitality.

"I never had too much hospitality here," he said, noting that the Patriots aren't exactly popular in Colts country, "until I went for it on fourth-and-2."

His gamble on that play at the New England 28 with 2:08 to go failed and led to the Colts' winning field goal in a 2009 regular-season game.

"Fans greeted us lots more and were awfully friendly" after that, he added.

All-Pro receiver Wes Welker wasn't familiar with the term when asked the same question.

"What is Hoosier hospitality? What does that consist of?" Welker asked to laughs before getting a full explanation from a local television reporter. "I think it will be a little strange practicing at the Colts' facility. I don't know how many people like that, but we'll be calm and polite and not try to rub it in, so I hope everyone is appreciative of it."

Belichick, dressed in a suit ? no hoodie for the coach this time ? also said All-Pro tight end Rob Gronkowski is "day to day" with a high left ankle sprain for next Sunday's NFL title game against the New York Giants. Gronkowski has been wearing a walking boot since being injured in the AFC title game.

"You've got to prepare for every one of these situations that come up," quarterback Tom Brady said of the possibility Gronkowski will be limited or sidelined. "You always have to have some contingency plans."

Brady knows the Giants will bring lots of heat with their pass rush, but for now he was more comforted by not having to face a local rival who frequently has put Brady on his back.

"I see Dwight Freeney's picture up there (on the stadium)," Brady said. "When you come to Indy and don't have to play him, we are very fortunate for that."

The Patriots drew about 25,000 fans to Gillette Stadium earlier Sunday for what Brady termed "a pep rally." Team owner Robert Kraft, who has had an emotional year ? his wife passed away last July and he was instrumental in resolving the NFL's lockout of the players ? was thrilled by the turnout.

"We had 25,000 people come to our stadium today to send the team off," Kraft said. "At the stadium today it was so special, the time we are in now, to have 25,000 of our fans cheer our team is a very emotional experience."

This is Kraft's sixth Super Bowl as owner, and he vividly recalled the days when the team was lucky to draw 25,000 for a game.

"I sat with those crowds. I sat in the stands for 34 years and we had one home playoff game, in 1978, which we lost to Houston," Kraft said. "And last Sunday, we were privileged to host our 15th playoff game."

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20120130/ap_on_sp_fo_ne/fbn_patriots_arrive

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Utah school bomb plot: from inspiration to prevention, Columbine had a part

One suspect in the Utah high school bomb plot interviewed the Columbine principal in December. Police were tipped off by a friend of the suspect who received a suspicious message.?

An apparent school bombing plot foiled this week in Utah illustrates how much the Columbine massacre still resonates more than 10 years later.

Skip to next paragraph

One of the Utah suspects was so fascinated by the 1999 mass shootings at Colorado?s Columbine High School that he visited the school in December and interviewed the principal.

But the lessons of Columbine, including the importance of encouraging students to come forward about anything that might indicate a threat of school violence ? also appear to have borne fruit in this case.

The 16-year-old suspect?s friend and classmate, Bailey Gerhardt, reported a suspicious text message to an administrator at Roy High School: ?If I told you to stay home on a certain day, would you?? the text read, the Salt Lake Tribune reports.

The minor boy, as well as 18-year-old Roy High School student Dallin Morgan, were arrested Wednesday on suspicion of conspiracy to commit mass destruction. Police say months of planning went into their plot to set off a bomb during an assembly at the 1,500-student school and then try to escape by stealing an airplane.

No school assemblies were imminent, but had Bailey not come forward, ?it could have been a disaster,? Roy police spokeswoman Anna Bond said Thursday. The minor had previously made a pipe bomb, and both students had information about school security cameras and had been using flight simulator software, police said.

The Columbine connection in this case is the most extreme example seen by several school safety experts interviewed by the Monitor. It?s not uncommon for students to joke about Columbine or to refer to it when making real threats, they say.

But ?to go as far as to interview the principal and physically go there ? sends a message that they were extremely committed to doing something,? says Kenneth Trump, president of National School Safety and Security Services in Cleveland.

Columbine Principal Frank DeAngelis told the Associated Press that the student in question, who is not being named because he is a minor, asked to interview him for a story for his school newspaper. Mr. DeAngelis often fields such requests, he said, but in light of the arrests in Utah, he won?t do such interviews without first clearing it with security officials, the AP reports.

Wanting to emulate, or outdo, an incident like Columbine doesn?t happen in a vacuum, triggered by the Columbine massacre alone, notes William Pollack, a Harvard psychiatry professor and school-violence expert. It?s more like a ?gating phenomenon,? he says, where people might study it to do harm and feel encouraged by it to go through that gate, ?but they won?t do that if they?re not already there? ? motivated and committed for other reasons, he says.

While more information is likely to emerge about possible motives for the alleged plot, Bailey commented to investigators that the suspect had been angry after a former girlfriend broke up with him. Both teens wanted ?revenge on the world,? according to quotes in court documents as reported by the Salt Lake Tribune.

Bailey?s willingness to come forward ?says something for the school environment,? says Dr. Pollack, who was involved in post-Columbine studies on school shooters and the reasons why bystanders do or don?t report suspicious information.

More and more school administrators have taken the lessons of such reports to heart and ?see safe school climates as essential,? Pollack says. And whether it?s about bullying or a bomb plot, ?kids are more willing to come forward in general to talk about difficulties, or fears they have that someone may be hurt.?

In too many schools, safety training for staff is on the decline because of budget cuts, Mr. Trump cautions. He says calls for consulting are increasing from lawyers who are suing because of negligence and lack of safety in schools, and decreasing from from schools trying to be proactive.

But some of the most important steps aren?t very dependent on school budgets, says William Modzeleski, a school-safety consultant to the US Department of Education. It?s about being willing to put in the time to open up lines of communication between kids and adults, he says. ?Kids want to be talked with and feel they can go to someone.?

Associated Press material was used in this report.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/uBOWeM5JVj4/Utah-school-bomb-plot-from-inspiration-to-prevention-Columbine-had-a-part

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Sunday, January 29, 2012

93% Mission: Impossible Ghost Protocol

Superbly directed action from the first minute to the last! Even if I still hold the original as my favourite in the series, the sensational stunts of this film is definitely one for the record books. The jaw-dropping sequence at the Burj Khalifa hotel - a rush of adrenaline that exhilarates to the extreme - comes especially to mind. Cast-wise, it's quite the pleasure as well. British funnyman Simon Pegg provides some nice comic relief (although corny such at times), while Paula Patton and Jeremy Renner bring out their absolute A-game. And for me as a Swede, it was an incredible, if somewhat surreal joy to see Michael Nyqvist as the villain. Just a few years ago, I would have never guessed him to take the leap over to Hollywood, but I'm sure glad that he did. Especially as he's one of the finest actors that our country has to present. As for the film's front figure, I can say only this: no longer may I have any respect for Tom Cruise the person (he's still a Scientologist after all), but he certainly hasn't faded one bit as a dare-devil action star. So what it boils down to here is one of the true must-see popcorn movies of 2011. Kudos to director Brad Bird, for making the impossible possible, and granting us an invite to a sequel that breathes new life into the franchise. He really pulled out all the stops on this one, delivering a fun and energizing, balls-to-the-wall action-fest. If it doesn't raise your pulse, you are either dead or made of stone. Because as far as spy thrillers go, this is one of the coolest ever conceived.

September 19, 2010

Source: http://www.rottentomatoes.com/m/mission_impossible_ghost_protocol/

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Saturday, January 28, 2012

Canada: A million reasons to celebrate - Aviva Canada announces the recipients of the 2011 Aviva Community Fund

25 January, 2012

Aviva Canada Inc is pleased to announce the recipients of the third Aviva Community Fund competition, and this year Canadians helped select 12 worthy ideas representing communities nationwide. A total of $1,000,000 will be awarded to these diverse local projects, including school yards in Ontario and Alberta, an animal rescue facility in British Columbia and a youth camp in Quebec, among others. This unique competition created by property and casualty insurer Aviva Canada aims to lead, empower and support community initiatives across the country.

?We?re proud to be able to support such a great group of organizations in their efforts to improve communities across Canada,? said Maurice Tulloch, president and CEO of Aviva Canada. ?We?d like to thank our broker partners who stepped up and got involved in the competition this year, along with our vendors and all Canadians that supported the Aviva Community Fund.?

Launched in September 2009, the Aviva Community Fund encourages Canadians to visit www.avivacommunityfund.org to share ideas and vote for causes that are meaningful to their communities. After several rounds of voting to identify Canada?s favourite ideas, a panel of independent judges is tasked with reviewing the causes and selecting the winners.

Aviva Canada would like to thank the numerous community partners that contributed to the Aviva Community Fund this year including Abilities Foundation, Benevity, Canadian Mental Health Association, Child Welfare League of Canada, Diabetes Hope Foundation, Essential Accessibility, Food Banks Canada, Free The Children, Learning for a Sustainable Future, March of Dimes, National Alliance for Children and Youth, ParticipACTION, Psychology Foundation of Canada, Seeds Foundation and Volunteer Canada.

Aviva Canada congratulates the winners of the 2011 Aviva Community Fund:

Kitchen Equipment to Help Feed Bodies and Soul: Kamloops, BC ? The PIT (People In Transition) Stop team serves meals to over 150 less fortunate members of the community every week at the Kamloops United Church. Support from the Aviva Community Fund will enable the PIT Stop team to add much needed equipment to their kitchen which is also used by community organizations and after school programs.

Northern Lights Wildlife Society, Bear Rescue Facility: Smithers, BC ? NLWS is a volunteer based charity dedicated to rehabilitating injured and/or orphaned juvenile wildlife back into the wild.?To aid in the growing demand on the bear rescue facility, the Aviva Community Fund will provide the resources to add fencing for a 10,000 square foot area, a shelter space and activity opportunities for the bears.

Holyrood School Courtyard Classroom: Edmonton, AB ? With support from Aviva Canada, Holyrood Elementary School will create a vibrant outdoor courtyard classroom. The classroom will be used by the students, a local senior?s centre, an extended care facility and group home. The classroom will include vegetable gardens, native shrubs, small trees, log seating and pathways.

GS Lakie Convertible Theatre/Summer Arts Institute: Lethbridge, AB ? Support from the Aviva Community Fund will allow GS Lakie Middle School to add lighting and other technical requirements to transform their multi-use foyer into a theatre to house summer arts programs, workshops and festivals for youth across Western Canada. The space can accommodate up to 700 spectators and is used by the school, various arts groups and the community at large.

Yorkton Skateboard, Bike and Walking Park: Yorkton, SK ? Yorkton was hit hard by flood waters in 2010, causing severe damage to many homes and businesses. As part of the Brodie Avenue Redevelopment Project, funding from the Aviva Community Fund will be matched by the City of Yorkton for the construction of a skateboard, bike and walking park.

Kate's Kause Accessible and Inclusive Playground: Elmira, ON ? Elmira does not currently have a playground that is accessible for those with disabilities. Through funding from Aviva Canada, Kate?s Kause will build a playground structure with access for those with physical limitations, while addressing the needs of children with cognitive, visual, sensory and auditory disabilities.

St John School's Field of Dreams: Guelph, ON ? St John School has a vision to see their entire playground and surrounding green space transformed into a shady, more naturalized and stimulating outdoor environment for students and the community. With support of the Aviva Community Fund, the school will add a junior kindergarten enclosure, outdoor classroom, outdoor reading room and a volleyball court.

St Joseph's Villa/S.M Gym (Seniors in Motion): ?Dundas, ON ? The SIM Gym at St Joseph?s Villa is a fitness program that supports active aging and reduces the impact of age-related injuries and health problems.?Funding from Aviva Canada will allow St Joseph?s to increase their space and SIM program by 75%, accommodate a growing wait list, add new programs, expand hours of operation and increase membership.

Cameron Street Public School's Yard Revitalization: Collingwood, ON ? Cameron Street Public School, with Funding from Aviva Canada, will create natural play spaces where children can play and learn throughout their property. Improvements include an outdoor classroom with a sensory and vegetable garden, landscaping, resurfaced baseball diamonds, tarmac areas and a natural playground.

Give our Lions a Place to Roar (Lincoln Centennial Public School): St Catharines, ON ? After over five years with no outdoor play structure, Lincoln Centennial Public School will use funding from the Aviva Community Fund to create an outdoor playground for their community and students, including a special-needs class.

The Cascades Club: Chelsea, QC ? The Cascades Club is an active waterfront community organization that has been operating summer camps, as well as swimming and various boating programs, since 1920. Support from Aviva Canada will assist in securing a 1/3 acre waterfront property so the 800 members and hundreds touched through outreach programs may enjoy and benefit from waterfront activities on the Gatineau River.

All Natural Play Area - Centre de plein air Domaine-Notre-Dame: Sainte-Catherine-de-la-Jacques-Cartier, QC ? The Centre de plein air Domaine-Notre-Dame is a camp facility that encourages education, respect and accountability. The camp uses science workshops, cooking creation and expression, physical games, horseback riding and general camping to help youth aged two to 14 to develop. Funding from Aviva Canada will help create a cooking laboratory, recycling amenities, resurfacing of sport areas as well as the addition of picnic tables and change room facilities.

-ends-

Media contact:
Glenn Cooper
Senior Manager, Public Relations
Desk: +1 416 288 2685
Mobile +1 416 523 3225
Email: glenn_cooper@avivacanada.com

Notes to editors:

About Aviva Canada
Aviva Canada is one of the leading property and casualty insurance groups in Canada providing home, automobile, recreational vehicle, group and business insurance to more than three million customers.?

A wholly-owned subsidiary of UK-based Aviva plc, the world's sixth-largest insurance group, the company has more than 3,000 employees, 30 locations and 1,700 independent broker partners. Aviva Canada and its employees invest in positive change including through the Aviva Community Fund and Eva's Initiatives, its partner in Aviva's global Street to School program to help homeless and other at-risk youth reach their potential.

For more information visit avivacanada.com, our blog (http://blog.avivacanada.com/) or our Twitter (www.twitter.com/avivacanada), Facebook (www.facebook.com/AvivaCanada) and LinkedIn (www.linkedin.com/company/aviva-canada) pages.

Source: http://www.aviva.com/media/news/15735/

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Finance chiefs reassure CEOs over European crisis

French Finance Minister Francois Baroin, left, speaks with his German counterpart Wolfgang Schaeuble, right, during a plenary session at the 42nd annual meeting of the World Economic Forum, WEF, in Davos, Switzerland, Friday, Jan. 27, 2012. The meeting lasts until Jan. 29. (AP Photo/Keystone, Jean-Christophe Bott)

French Finance Minister Francois Baroin, left, speaks with his German counterpart Wolfgang Schaeuble, right, during a plenary session at the 42nd annual meeting of the World Economic Forum, WEF, in Davos, Switzerland, Friday, Jan. 27, 2012. The meeting lasts until Jan. 29. (AP Photo/Keystone, Jean-Christophe Bott)

US Secretary of Treasure Timothy F. Geithner talks about US Economy during a plenary session at the 42nd annual meeting of the WEF in Davos, Switzerland, Friday, Jan. 27, 2012. The meeting lasts until Jan. 29. (AP Photo/Anja Niedringhaus)

President of the European Central Bank Mario Draghi speaks during a session at the World Economic Forum in Davos, Switzerland, Friday, Jan. 27, 2012. Draghi said that new, tougher rules restricting government budget deficits are the prerequisite before the troubled eurozone can move toward more central control of finances. (AP Photo/Michel Euler)

President of the European Central Bank Mario Draghi pauses as he speaks during a session at the World Economic Forum in Davos, Switzerland, Friday, Jan. 27, 2012. Draghi said that new, tougher rules restricting government budget deficits are the prerequisite before the troubled eurozone can move toward more central control of finances. (AP Photo/Michel Euler)

President of the European Central Bank Mario Draghi pauses as he speaks during a session at the World Economic Forum in Davos, Switzerland, Friday, Jan. 27, 2012. Draghi said that new, tougher rules restricting government budget deficits are the prerequisite before the troubled eurozone can move toward more central control of finances. (AP Photo/Michel Euler)

(AP) ? Leading finance chiefs sought to reassure anxious global business leaders on Friday that Europe is on track to solve its crippling debt crisis before it drags the world's economies down. Europe's top banker said investors, burned after trusting the region's governments too much, now trust them too little.

The finance chiefs said the picture in Europe has changed over the past two months as the European Central Bank has loaned billions of euros to fragile banks, indebted countries have pushed through convincing reforms and EU leaders have come near to building a closer fiscal union that would make their common currency stronger.

Several also signaled Friday that Greece is close to clinching a crucial debt-reduction deal with private bondholders ? a key element in Europe's efforts to stem a two-year debt crisis that is causing ripples around the globe. The crisis is a central topic at the World Economic Forum, a gathering of government and business leaders at the Swiss ski resort of Davos.

"They're making progress on reforms, they're changing the institutions of Europe to put better discipline on fiscal policy," said U.S. Treasury Secretary Timothy Geithner. "You have three new governments doing some very tough things. You have an ECB doing what central banks have to do. You see them move to try to strengthen the financial sector."

Mario Draghi, head of the European Central Bank, said a combination of actions ? including super-cheap, long-term loans to shaky banks on the continent and a couple of interest rate cuts ? have turned the crisis around.

"We have avoided a major credit crunch, a major lending crisis," he said.

Draghi said borrowing rates would remain high "for quite a while" because bond markets are overestimating the risk involved in holding European government debt after years of underestimating it. But he called market pressure "the most potent engine for reform in different governments."

Geithner said the fate of the U.S. economy ? and by extension of the rest of the world ? hinges on Europe's debt crisis, along with potential tensions with Iran. He said the main piece of unfinished business for Europe is building a bigger fund to help troubled economies survive.

But while French Finance Minister Francois Baroin said that fund needs to be increased to calm markets, his German counterpart, Wolfgang Schaeuble, indicated that his government is not prepared to do so. Germany, as Europe's biggest economy, would face the biggest bill.

"We must not give the wrong incentives," Schaeuble said. "You can make any figure. It will not work if the real problems will not be solved."

Both, together with Spanish Economy Minister Luis de Guindos Jurado and European Monetary Affairs Commissioner Olli Rehn, agreed that the idea of issuing "eurobonds" backed jointly by all eurozone governments is a non-starter for now. They didn't rule out the possibility that such bonds could be introduced once confidence in Europe's public finances is restored, with Guindos calling that a "final target."

Schaeuble said eurobonds would provide bad incentives by allowing debt-ridden countries to "spend money you don't have on the bill of others."

Many economists have said eurobonds are needed to solve the crisis as they could reduce the borrowing costs of heavily indebted countries by pooling them with bonds of stronger economies like Germany's.

European leaders have been especially concerned about Greece, whose borrowing costs are so high that it needs a second European bailout just to pay its interest, but the finance chiefs signaled Friday that a deal is at hand.

Greece has been negotiating with the a group representing banks and other lenders in the hopes that they will forgive half of Greece's debt in exchange for Greek assurances that it will pay back the other half without defaulting on its loans. The deal would also let Greece repay over a longer period at a lower interest rate ? negotiators have been trying to agree on what that rate will be.

Schaeuble said he is "quite optimistic" about a deal, while Rehn said he hopes a deal can be reached "if not today, maybe by the weekend."

Agreement between Greece and its creditors is needed before Europe and the International Monetary Fund agree to a second multibillion-euro bailout package.

At the heart of the problem is that the 17 countries that use the euro use a single currency but have different fiscal policies. That changes the nature of their debt, said Adair Turner, chairman of Britain's banking regulator the Financial Services Authority.

"That debt is more equivalent to the State of California debt than the U.S. federal debt," he said.

That's why all but one of the 27 EU countries ? the United Kingdom has refused to participate ? are discussing a closer fiscal union. On Monday, leaders meet in Brussels to work out the details of that new compact.

Schaeuble and Baroin noted that even the agreement in principle to forge closer ties has calmed markets since a December summit, as borrowing rates have dropped and stock markets have risen.

"It's amazing," Draghi said. "If you compare today with even five months ago, the euro area is another world."

The crisis threatens more than Europe: the U.N.'s refugee chief warned Friday that it is fueling conflicts around the world. Antonio Guterres told The Associated Press that rising food prices and growing unemployment are hitting those already at the bottom hardest, sparking conflict in places like South Sudan and exacerbating hotspots including Afghanistan, Iraq and Somalia.

_____

Frank Jordans in Davos and David McHugh in Frankfurt, Germany contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-01-27-EU-Davos-Forum/id-539fbff7748e4bc6b2860f7239b6e668

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Friday, January 27, 2012

Apollo 1: the fire that shocked NASA

The Apollo 1 Command Module after the fire that claimed the lives of Gus Grissom, Ed White, and Roger Chaffee. Credit: NASA.

NASA?s Apollo program began with one of the worst disasters the organization has ever faced. A routine prelaunch test turned fatal when a fire ripped through the spacecraft?s crew cabin killing all three astronauts. Today marks the 45th anniversary of the Apollo 1 fire, a tragic and preventable accident. There were warning signs, similar accidents that had claimed lives both in the United States and abroad. The Apollo 1 crew could have been saved from a gruesome death.

Plugs Out

L-R: Roger Chaffee, Ed White, and Gud Grissom training for their Apollo 1 flight. Credit: NASA.

The commander for Apollo 1 was Gus Grissom, one of the original Mercury astronauts whose first spaceflight was marred by his capsule?s sinking after splashdown. He flew again in Gemini in a spacecraft he named ?Molly Brown.? Senior pilot on the Apollo 1 crew was Ed White, a Gemini veteran who made America?s first spacewalk in 1965. Rounding out the crew was pilot Roger Chaffee, a talented rookie more than capable of holding his own with his experienced crew mates. He was a notoriously good guy who took pains to thank everyone for their contributions to Apollo right down to the janitors.

By the end of January 1967, the crew was going through their final prelaunch tests; barring some major setback, they would make the first manned Apollo flight on February 21. One routine test NASA had done since Mercury was the ?plugs out? test, a final check of the spacecraft?s systems.

The spacecraft - Command Module 12 - arrives at the Kennedy Spaceflight Centre clearly destined for Apollo 1. Credit: NASA.

The spacecraft was fully assembled and stacked on top of its unfuelled Saturn IB launch vehicle on pad 34. The umbilical power cords that usually supplied power were removed ? the plugs were out ? and the spacecraft switched over to battery power. The cabin was pressurized with 16.7 pounds per square inch (psi) of 100 percent oxygen, a pressure slightly greater than one atmosphere. With everything just as it would be on February 21, the crew went through a full simulation of countdown and launch.

A full launch-day staff of engineers in mission control also went through the simulation. The White Room, the room through which the astronauts entered the spacecraft, remained pressed next to the vehicle. A crew of engineers monitored the spacecraft and were just feet away from the astronauts.

Cosmonaut Bondarenko. Credit: spacefacts.de

Grissom, White, and Chaffee suited up and entered the Apollo 1 command module at 1pm and hooked into the spacecraft?s oxygen and communications systems. For the next five and a half hours, the test proceeded with only minor interruptions. Grissom?s complaint of a smell like sour buttermilk in the oxygen circulating through his suit was resolved after a short hold, and a high oxygen flow through the astronauts suits tripped an alarm. But these were minor problems and didn?t raise any red flags in mission control.

The real problem was communication. Static made it impossible for the crew and mission control to hear one another. An increasingly frustrated Grissom began to question how they were expected to get to the Moon if they couldn?t talk between a few buildings.

The Apollo 1 official crew portrait. L-R: Ed White, Gus Grissom, Roger Chaffee. Credit: NASA.

Just after 6:31 that evening, the routine test took a turn. Engineers in mission control saw an increase in oxygen flow and pressure inside the cabin. The telemetry was accompanied by a garbled transmission that sounded like ?fire.? The official record reflects the communications problem. The transmission was unclear, but the panic was obvious as an astronaut yelled something like ?they?re fighting a bad fire ? let?s get out. Open ?er up? or ?we?ve got a bad fire ? let?s get out. We?re burning up.? The static made it impossible to hear the exact words or even distinguish who was speaking.

But flames visible through the command module?s small porthole window left no doubt about what the crew had said. Engineers in the White Room tried to get the hatch open but couldn?t. It was an inward opening design, and neither engineers outside the spacecraft nor the astronauts inside were strong enough to force it open. The men in mission control watched helplessly as the scene played out on the live video feed.

The Apollo 1 crew in a less formal setting. L-R: Gus Grissom, Ed White, Roger Chaffee. Credit: NASA.

Just three seconds after the crew?s garbled report of a fire, the pressure inside the cabin became so great that the hull ruptured. Men wrestling with the hatch were thrown across the room as flames and smoke spilled into the White Room. Many continued to fight their way towards the spacecraft but were forced to retreat as the smoke grew too thick to see through. In mission control, the telemetry and voice communication from Apollo 1 went completely silent.

An hour and a half later, firemen and emergency personnel succeeded in removing the bodies; Ed White was turned around on his couch reaching for the hatch. Over the next two months, the spacecraft was disassembled piece by piece in an attempt to isolate the cause of the fire. The full investigation lasted a year.

The Apollo 1 crew floats around during water egress training. Credit: NASA.

The Apollo 1 accident review board determined that a wire over the piping from the urine collection system had arced. The fire started below the crew?s feet, so from their supine positions on their couches they wouldn?t have seen it in time to react. Everything in the cabin had been soaking in pure oxygen for hours, and flammable material near the wire caught fire immediately. From there, it took ten seconds for spacecraft to fill with flames.

The crew?s official cause of death was asphyxiation from smoke inhalation. Once their oxygen hoses were severed they began breathing in toxic gases. All three astronauts died in less than a minute. Many who had tried to save them were treated for smoke inhalation.

The Chamber of Silence

Astronaut Frank Borman's official Gemini era portrait. Borman was the astronaut's representative on the Apollo 1 accident review board. Credit: NASA.

The fire that claimed the lives of Grissom, White, and Chaffee is eerily similar to one that killed cosmonaut Valentin Bondarenko in 1961. Bondarenko was known to his colleagues as a congenial and giving man with great athletic prowess who worked tirelessly to prove he deserved the honour of flying in space.

Part of the cosmonauts? training was done in an isolation chamber designed to mimic the mental stresses spaceflight. The room, which the men called the Chamber of Silence, was spartan to say the least. It was furnished with a steel bed, a wooden table, a seat identical to what they would have in the Vostok capsule, minimal toilet facilities, an open-coil hot plate for warming meals, and a limited amount of water for washing and cooking. The chamber was pressurized to mimic the capsule?s environment in space. In this case, the oxygen concentration was 68 percent.

Ed White III touches his father's name on the Apollo 1 panel of the Space Mirror Memorial at the Kennedy Space Centre visitor complex. Credit: NASA.

During the test, cosmonauts would exercise mental agility with memory games using a wall chart with coloured squares. They would keep busy by reading or colouring ? subjects were supplied with some leisure material. The silence was frequently interrupted by classical music to see how the subjects reacted to a pleasurable shock. Aside from these distractions, sensory deprivation inside the chamber was absolute. The room was mounted on thick rubber shock absorbers that muffled any vibrations from movement outside, and the 16-inch thick walls absorbed any sound. The cosmonauts communicated with doctors by lights. A light told the subject to apply medical sensors to his body, and a light outside the chamber signaled to doctors that they could begin their tests. A different light would signal the end of the isolation test.

The environment was designed to challenge the cosmonauts? mental stability and adaptability. But the hardest part was that no subject knew beforehand how long his test would last. It could run anywhere from a few hours to weeks.

The Apollo 1 crew walks across the gantry before entering the spacecraft on January 27. Credit: NASA.

Bondarenko was the 17th cosmonaut to go into the Chamber of Silence and on March 23, his ten day test came to an end. A light signaled that technicians outside had started depressurizing the chamber to match the atmosphere outside. It was a routine part of the test, but this time it was interrupted by a fire alarm.

While he waited to leave the chamber, Bondarenko removed his biomedical sensors and wiped the adhesive off with rubbing alcohol on a cotton pad. In his haste to leave, and exhibiting the lack of concentration expected after ten days of mental testing, he didn?t look where he threw the pad. It landed on the hot plate?s coil. Cosmonaut Pavel Popovich theorized that he had been standing next to it at the time. Many subjects left the small heater on all the time to warm up the chilly room.

A dummy rides in a Vostok capsule seat. Credit: Associated Press.

A fire sparked and spread in an instant; everything, including Bondarenko, was saturated with a high concentration of oxygen. Technicians wrenched the door open and exposed the chamber to air, killing the fire instantly, but the damage was done. Doctors pulled a huddled and severely burnt Bondarenko from the room. ?It?s my fault,? he whispered when doctors reached him, ?I?m so sorry? no one else is to blame.? The severity of the fire was immediately obvious. Bondarenko?s wool clothes had melted onto his body and the skin underneath had burned away. His hair had caught fire. His eyes were swollen and melted shut.

In Moscow, surgeon and traumatologist Vladimir Julievich Golyakhovsky got a frantic call at his office; the severely burned patient was on his way. Ten minutes later, a team of men in military uniforms arrived carrying the blanket-wrapped cosmonaut. They were accompanied, Golyakhovsky later recalled, by an overwhelming smell of burnt flesh.

The damage to the Apollo 1 crew cabin, after the bodies were removed and before the disassembly began. Credit: NASA.

Bondarenko pleaded for something ?to kill the pain.? Golyakhovsky obliged and gave the patient a shot of morphine in the soles of his feet. It was the one unscathed part of his body thanks to his heavy boots, and the only place the doctor could find a vein. There was nothing he could do to save the man?s life. Bondarenko died the next morning. The official cause was shock and severe burns.

Lessons at Home

Parallels between the Apollo 1 crew?s and Bondarenko?s deaths are obvious, but how each space agency dealt with the deaths was very different. Grissom, White, and Chaffee were each given very public funerals in accordance with their respective military traditions. Bondarenko?s death was kept secret, his identity covered by a pseudonym. Not until 1986 did the world hear the true story of his death. This has bred speculation that had the Soviet system been more open, NASA would have know about the dangers of training in a pressurized pure oxygen environment and could have saved the Apollo 1 crew. Former cosmonaut Alexei Leonov even suggested that the CIA knew about Bondarenko since the US had pierced the Iron Curtain before the accident.

But this is unlikely. And besides, NASA wouldn?t need to look to the Soviet Union to know the dangers of testing in a pressurized oxygen environment. There were enough incidents in the US to make the danger very clear. Four oxygen fires in the five years before the Apollo 1 accident were proof enough.

The Apollo 1 spacecraft nearing the end of the disassembly. Sometime towards the end of March, 1967. Credit: NASA.

On September 9, 1962, a fire broke out in a simulated spacecraft cabin at Brooks Air Force Base. The cabin was pressurized to 5psi with pure oxygen. Both subjects were protected by pressure suits. Neither sustained burns, but both were treated for smoke inhalation.

Two months later on November 16, four men had been inside the US Navy?s Air Crew Equipment Laboratory for 17 days in an environment pressurized to 5psi of 100 percent oxygen when an exposed wire arced and started a fire. It spread rapidly over the men?s clothing and hands for 40 seconds before they were rescued. All were treated for severe burns, and this was the only instance in which the source of the fire was identified.

Two Navy divers were killed on February 16, 1965 in a test of the Navy?s Experimental Diving Unit, which was pressurized to 55.6psi to mimic conditions at a depth of 92 feet. It was a multi-gas environment: 28 percent oxygen, 36 percent nitrogen, and 36 percent helium. Somehow, the carbon dioxide scrubbers that were designed to remove the toxic gas from the air caught fire. Pressure inside the chamber rose making it impossible for technicians outside to open the door and remove the men.

Gus Grissom's funeral procession. Credit: NASA.

A 1966 oxygen environment fire came frighteningly close to anticipating the Apollo 1 accident. A fire broke out during an unmanned qualification test of the Apollo Environmental Control System on April 28. The cabin was pressurized to 5psi of 100 percent oxygen, just like the spacecraft would be in flight. The fire was blamed on a commercial grade strip heater inside the cabin and the incident was consequently dismissed. The commercial material would not be onboard any manned flights. The board that investigated the accident made no mention of the hazardous environment.

A Lack of Imagination

The Apollo 1 mission patch. Credit: NASA.

These accidents weren?t secret. NASA knew the dangers of a pressurized oxygen environment, which has prompted conspiracy theorists to suggest that the space agency intentionally put the Apollo 1 crew in danger. But this was hardly the case. In truth, no one at NASA gave much thought to a fire in the spacecraft.

In the early 1960s when Apollo was in its preliminary stages, a dual gas system (likely oxygen and nitrogen) was proposed for the crew cabin. This would have been safer in the event of fire, but more difficult overall. A mixed gas environment requires more piping and wiring, which in turn adds weight. Pure oxygen was simpler, lighter, and was already familiar to NASA. The dual-gas idea was scratched.

NASA did address the possibility of a fire in the spacecraft, but only developed procedures for an event in space when the nearest fire station was 180 miles away. Apollo, like Mercury and Gemini, had no specific fire fighting system on board. The 5psi of oxygen in space was considered too thin to feed a significant fire. Anything that could spark in that environment could be taken care of with a few well aimed blasts from the astronauts? water pistol.

Grissom's, White's, and Chaffee's death are the cover story of Life Magazine's February 10 issue. Credit: Life.

There was no procedure for a fire on the ground. With so many engineers on hand for every test, it was assumed that the astronauts would safe so long as fire extinguishers were nearby. But more importantly in the case of Apollo 1 is the plugs out test?s status: it wasn?t classified as dangerous.

Frank Borman, a Gemini veteran who would go to the Moon on Apollo 8, served as the astronaut?s representative to the Apollo 1 accident investigation board. He made this point about the plugs out test?s status abundantly clear. ?I don?t believe that any of us recognized that the test conditions for this test were hazardous,? he said on record. Without fuel in the launch vehicle and all the pyrotechnic bolts unarmed, no one imagined a fire could start let alone thrive. Borman himself hadn?t thought twice when he went through the plugs out test before his Gemini 7 mission. He was confident in NASA and its engineers and stated on record that he would have gone through the Apollo 1 test had he been on the crew.

The Apollo 1 crew expressed their concerns over the Apollo spacecraft in a joke crew portrait. They said a little prayer, and gave the picture to the manager of the Apollo Spacecraft Program Office Joe Shea in 1966. Credit: NASA.

Borman alluded to the Apollo 1 crew?s shared confidence. There had been problems with Apollo?w development, and every astronaut had the right to refuse to enter a spacecraft. ?Although there are sometimes romantic silk-scarf attitudes attributed to this type of business, in the final analysis we are professionals and will accept risk but not undue risks,? explained Borman. The Apollo 1 crew felt the dangers were minimal.

With that statement, Borman identified what he considered the crux of the problem and the real reason, however indirect, behind the death of the crew. ?We did not think,? he said, ?and this is a failing on my part and on everyone associated with us; we did not recognize the fact that we had the three essentials, an ignition source, extensive fuel and, of course, we knew we had oxygen.?

A plaque commemorating the Apollo 1 crew on what's left of launch pad 34. Credit: Christopher K. Davis (via Wikipedia).

Gus Grissom serendipitously wrote his memoirs during the Gemini program. He addresses the inherent risk of spaceflight in the book?s final passage. ?There will be risks, as there are in any experimental program, and sooner or later, inevitably, we?re going to run head-on into the law of averages and lose somebody. I hope this never happens? but if it does, I hope the American people won?t feel it?s too high a price to pay for our space program. None of us was ordered into manned spaceflight. We flew with the knowledge that if something really went wrong up there, there wasn?t the slightest hope of rescue. We could do it because we had complete confidence in the scientists and engineers who designed and built our spacecraft and operated our Mission Control Centre? Now for the moon.?

Though tragic, their deaths were not in vain. The substantial redesigns made to the Apollo command module after the fire yielded a safer and more capable spacecraft that played no small role in NASA reaching the moon before the end of the decade. It is a fitting tribute to the crew that the plaque on the pad where they perished reads ?ad astra per aspera? ? a rough road to the stars.

Suggested Reading:

- Official Apollo 1 site:?http://www.hq.nasa.gov/office/pao/History/Apollo204/

- Colin Burgess and Rex Hall. The First Soviet Cosmonaut Team. 2009.

- Gus Grissom. Gemini. 1968.

- Apollo 204 Accident. Report of the Committee on Aeronautical and Space Science, United States. 1968. Available online:?http://klabs.org/richcontent/Reports/Failure_Reports/as-204/senate_956/index.htm

- Report of the Apollo 204 Review Board to the Administrator, National Aeronautics and Space Administration. 1968. Available online:?http://www.hq.nasa.gov/office/pao/History/Apollo204/content.html

- Hearings Before the Subcommittee on NASA Oversight of the Committee on Science and Astronautics. 1967.

Source: http://rss.sciam.com/click.phdo?i=6e0fca39b4ba5f158568518f967d735a

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Pharma's niche focus spurs US aid for antibiotics (AP)

WASHINGTON ? The pharmaceutical industry won approval to market a record number of new drugs for rare diseases last year, as a combination of scientific innovation and business opportunity spurred new treatments for diseases long-ignored by drug companies.

Drug companies are increasingly taking advantage of the commercial benefits of developing so-called orphan drugs, which include extra patent protections, higher pricing and a streamlined review process by FDA. Among the innovative treatments approved in the past year were the first new drug for lupus in 50 years and the first new drug for Hodgkin's lymphoma in 30 years.

But the focus on specialty drugs has put pressure on the U.S. government to ramp up its own spending on vaccines, antibiotics and drugs for more widespread health threats, which are less profitable for companies.

Since 2006, government spending on research for familiar diseases like staph infections, smallpox and botulism has increased more than 660 percent, from $54 million to $415 million last year

"Many of these are everyday, general diseases that we thought we had conquered decades ago, but we've seen some of them pop up again," said Dr. Robin Robinson, director of the Biomedical Advanced Research and Development Authority, which is tasked with acquiring vaccines, drugs and other necessities for public health emergencies.

Since 2005, BARDA has awarded $3.5 billion to outside companies to encourage research and production of antibiotics, flu vaccines and other products that are seen as less profitable than specialty drugs.

"We have pushed the envelope more toward diminishing the risk for companies so that they'll be more interested in getting involved with us and developing things like vaccines and antivirals," said Dr. Anthony Fauci, infectious diseases chief at the National Institutes of Health, which funds research into bird flu, tuberculosis and other potential pandemics. The government's role in developing new therapies goes beyond awarding contracts and includes offering assistance in designing trials and recruiting test subjects.

The need for such assistance stems in part from a new focus among pharmaceutical companies on drugs for rare diseases or unusual strains of common diseases.

Eleven of the 30 new drugs approved last year, or 37 percent, were for rare medical conditions, the highest percentage on record since the FDA began offering incentives to develop such therapies, known as orphan drugs, about 30 years ago. Additionally, nearly half of the 30 drugs were cleared under FDA's "fast track" program reserved for drugs that fill an unmet medical need.

"The companies are saying `this is actually a viable model.' Whereas back in the nineties they were skeptical, now they seem convinced," said Mark Schoenebaum, an analyst with International Strategy & Investment.

Analysts credit scientific advances and looming patent expirations with the spate of innovative products. Drugs worth a mammoth $255 billion in global annual sales are set to go off patent before 2016, according to EvaluatePharma Ltd., a London research firm.

The pharmaceutical industry reached its peak of profitability in the 1990s with heavily marketed drugs for common afflictions, like AstraZeneca PLC's Nexium pill for heart burn and Pfizer Inc.'s Lipitor for high cholesterol. In the last decade drugmakers managed to extend the patents on those drugs by tweaking their formulations, resulting in so-called `follow-on' drugs. But with most of those products on the cusp of losing patent protection, drugmakers have finally been forced to innovate, often turning to hard-to-treat diseases for which there are few existing therapies.

The FDA grants companies seven years of exclusive, competition-free marketing for each newly approved orphan drug, as well as tax breaks on the costs of developing the drugs. Orphan drugs also typically command much higher prices than other drugs. Last year French drugmaker Sanofi paid $20 billion to acquire specialty drugmaker Genzyme, whose products range from $100,000 to $300,000 for one year's supply.

One side effect of the focus on developing drugs for rare diseases is increased investment by the government to spur research into more common public health threats with the potential to cause mass outbreaks of illness. One such threat comes from so-called superbugs, or bacteria that have grown resistant to antibiotic drugs.

Robinson says government support is needed to spur antibiotic development because of how sparingly the products are used in medical practice. After decades of routine use, many first-generation antibiotics like penicillin are no longer effective against common bacterial strains, such as the staphylococcus aureaus, which causes staph infections. Physicians are encouraged to use newer antibiotics only in critical situations so that superbugs have less chance to build a resistance to them. As a result, drugmakers do not see a large commercial market for new antibiotics. Now the federal government is providing an incentive.

BARDA has awarded a series of contracts to encourage development of new antibiotics that can be stockpiled for use in a natural outbreak or during a bioterrorism attack.

? The agency has allocated up to $64 million to Achaogen, a San Francisco startup, for development of a new antibiotic against tularemia, a bacterium that can cause pneumonia and urinary tract infections. Public health officials are especially focused on Tularemia because it could also be used in a potential bioterrorism attack. Robinson says the contract is an example a new strategy of encouraging companies to produce therapies with dual uses: as federal preparatory measures and as commercial medical products.

Achaogen has received $155 million in research contracts and has several antibiotics in early and mid-stage, though none are currently available for sale.

? Under a $38.5 million contract awarded in September, BARDA will help GlaxoSmithKline PLC test an experimental antibiotic against both bioterrorism agents and infections like hospital-acquired pneumonia.

The U.S. government has used a similar pump priming strategy to encourage investment in flu vaccines. The Department of Health and Human Services wants to be able to provide enough vaccine for the entire U.S. population within six months of a flu pandemic. To meet that goal the government has tried to boost vaccine production by encouraging more Americans to get the standard flu vaccine each year. The government's hope is that by making the shots routine for more Americans, companies will invest in larger vaccine facilities that can ramp up production in the event of a pandemic.

Last month Swiss drugmaker Novartis AG opened the first U.S. vaccine facility equipped with cell culture technology, a faster method for producing vaccines than the traditional technique using chicken eggs. The U.S. government provided half of the $1 billion investment for the facility, as part of its preparations for a potential flu pandemic.

Source: http://us.rd.yahoo.com/dailynews/rss/health/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_he_me/us_dread_disease_aid

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Thursday, January 26, 2012

Is moon base really the 'weirdest' Newt Gingrich idea? Maybe not.

Newt Gingrich once wrote a bill that proposed to clarify when a moon base could apply for statehood. He admitted the bill was a bit odd Wednesday. But it might now prove to be a stroke of brilliance.?

Newt Gingrich wants to establish a colony on the moon, in case you haven?t heard. At a campaign stop on Florida?s Space Coast Thursday he promised that the US would have a permanent lunar base by the end of his second term in the Oval Office.

Skip to next paragraph

He talked about it as if it would be a lunar Plymouth, mankind?s brave foray into a lunar unknown, though he himself did not make that direct comparison. He even put out some ideas as to how the place should be governed.

When Moon Base Gingrich holds enough people, it should apply for statehood, he said.

?I think the moon primary would come late in the [campaign] season,? he said, smiling. This was either hubristic or charmingly self-aware, depending on how one views the prospect of the former speaker in the White House.

As Gingrich noted Wednesday, he?s outlined his ideas for space self-government before. As a young member of Congress in 1981, he introduced a bill he now refers to as the Northwest Ordinance for Space, but back then went by the more prosaic name of National Aeronautics and Space Policy Act of 1981.

BuzzFeed has dug up an actual copy of this legislation from the Library of Congress, and it?s pretty interesting. Much of it consists of an order to NASA to set 30-year goals for everything from a new ?operational world information system? (Newt invented the Internet!) to manned Mars and moon missions.

Title IV covers ?Government of Space Territories.? It begins in a sweeping manner: all persons residing in any US space community (which could be anywhere from the moon to Jupiter, we guess) ?shall be entitled to the protection of the Constitution of the United States.?

Wow ? this means that any terror suspect caught at a US moon base couldn?t be shipped to Guant?namo, right? Also, any baby born to an illegal US moon base immigrant would be a US citizen, raising the possibility of moon birth tourism.

The second section of Title IV says that when a US space colony holds 20,000 people, it will be able to hold a convention to establish a constitution and form of self-government for itself. Kind of like Philadelphia in 1787, only with external oxygen supplies.

Title IV?s third section establishes that whenever said space colony holds the same number of people as the least populous US state (right now, that?s Wyoming, at 544,270) it will be admitted as a US state ?on an equal footing with the original states.?

That raises a question ? if you?re the senator from the moon, would you get in trouble with constituents for not traveling home often enough to take the pulse of Tranquility Base? Because you probably couldn?t do that Friday-to-Monday.

Anyway, Gingrich himself kind of poked fun at himself for all this, saying that he?s old enough to have read ?Missiles & Rockets Magazine? as a kid, and that the whole thing might be the ?weirdest? policy idea he?s ever proposed.

But let?s be honest ? he?s running a Florida primary, and Florida?s Space Coast right now suffers from high unemployment. Gingrich might be crazy like a space fox here.?

Slate?s Dave Weigel wrote about Gingrich?s speech under the head ?Not Actually Crazy.?

?It?s an idea that makes the New York/Washington-Alinskyite media guffaw. It also happens to be a pander to local voters that no one will try to make,? wrote Mr. Weigel.

After all, in the late 1960s, NASA drew up plans to establish a moon base by 1980 and send men to Mars by 1983. But these were cancelled by then-President Richard Nixon, notes Space.com in an outline of presidential visions for space exploration.

Nixon was worried that the government spending was too high ? and NASA was a convenient target.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/5Rex4Gz40D4/Is-moon-base-really-the-weirdest-Newt-Gingrich-idea-Maybe-not

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iPhone Outsells All Verizon Android Phones Combined

That iPhone 4S really sucks, huh? Not only did Apple sell 37 million iPhones in the last three months, the “disappointing” iPhone also outsold Android at Verizon. To be clear, Verizon sold more iPhone 4S units that all Android handsets combined. The figures, revealed at Verizon’s own earnings report yesterday, show that the carrier shifted [...]

Source: http://feedproxy.google.com/~r/GearFactor/~3/Eef3Hsh9wnM/

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Wednesday, January 25, 2012

Patterns of chromosome abnormality: The key to cancer?

Monday, January 23, 2012

A healthy genome is characterized by 23 pairs of chromosomes, and even a small change in this structure ? such as an extra copy of a single chromosome ? can lead to severe physical impairment. So it's no surprise that when it comes to cancer, chromosomal structure is frequently a contributing factor, says Prof. Ron Shamir of the Blavatnik School of Computer Science at Tel Aviv University.

Now Prof. Shamir and his former doctoral students Michal Ozery-Flato and Chaim Linhart, along with fellow researchers Prof. Shai Izraeli and Dr. Luba Trakhtenbrot from the Sheba Medical Center, have combined techniques from computer science and statistics to discover that many chromosomal pairs are lost or gained together across various cancer types. Moreover, the researchers discovered a new commonality of chromosomal aberrations among embryonic cancer types, such as kidney, skeleton, and liver cancers.

These findings, recently published in Genome Biology, could reveal more about the nature of cancer. As cancer develops, the genome becomes increasingly mutated ? and identifying the pattern of mutation can help us to understand the nature and the progression of many different kinds of cancer, says Prof. Shamir.

Looking at the big picture

As cancer progresses, the structure of chromosomes is rearranged, individual chromosomes are duplicated or lost, and the genome becomes abnormal. Some forms of cancer can even be diagnosed by identifying individual chromosomal aberrations, notes Prof. Shamir, pointing to the example of a specific type of leukemia that is caused by small piece of chromosome 9 being moved to chromosome 22.

When analyzing many different kinds of cancer, however, the researchers discovered that chromosomal aberrations among different cancers happen together in a noticeable and significant way. The researchers studied a collection of more than fifty thousand cancer karyotypes ? representations of chromosomal layouts in a single cell ? and charted them according to commonalities. The researchers were not only able to confirm different chromosomal aberrations that appeared in specific cancer types, but also for the first time identified a broader effect of pairs of chromosomes being lost or gained together across different cancer types.

It was also the first time that researchers saw a connection among solid kidney, skeleton, and liver cancers. While it was known that these cancers all develop in the embryo, they were previously analyzed independently. The TAU researchers have now confirmed that they share chromosomal characteristics and aberrations, much like various forms of leukemia or lymphomas.

Aberrations a driving force for cancer

Under normal circumstances, even a small change to a person's chromosomal structure can be devastating. For example, Down's syndrome is caused by a single extra copy of Chromosome 21. "But in cancer, there are many cases of extra or missing chromosomes. Yet cancer cells thrive more effectively than other cells," Prof. Shamir says.

Prof. Shamir hopes that future investigation into these chromosomal aberrations will give researchers more clues into why something that is so detrimental to our healthy development is so beneficial to this disease. Cancer is the result of sequences of events, he says, each causing the genome to become more mutated, mixed, and duplicated. Tracking these changes could aid our understanding of the driving forces of cancer's progress.

###

American Friends of Tel Aviv University: http://www.aftau.org

Thanks to American Friends of Tel Aviv University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/116946/Patterns_of_chromosome_abnormality__The_key_to_cancer_

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HIV-infected man fights to become Atlanta officer (AP)

ATLANTA ? A former investigator with the city of Los Angeles claims Atlanta police rejected his job application solely because he has HIV, a decision he said breaks the law and perpetuates stereotypes about people with the virus.

Atlanta police argue hiring the man poses a threat to the health and safety of the public, setting up a legal fight that is being followed closely by gay rights groups and police agencies.

A federal appeals court is scheduled to hear arguments in the case Wednesday, and judges will have the chance to pepper both sides with questions.

"It's shocking and frustrating and very saddening that in 2012 this is still going on," said the 40-year-old man who sued the city of Atlanta in 2010 under the pseudonym Richard Roe. "People are living with HIV and, for the most part, they are living normal lives and productive lives."

Roe spoke to The Associated Press on the condition of anonymity because he believes his medical condition could prevent him from other job opportunities.

Roe's anonymous lawsuit mirrors a battle that has largely been waged quietly, without high-profile protests or marches. Several similar lawsuits have been dismissed by judges who sided with the police departments, or the cases were settled out of court, the agreements kept confidential.

A lower judge sided with the city of Atlanta in November 2010 and threw out the lawsuit, ruling that Roe failed to prove he didn't pose a "direct threat" to the health and safety of others. Roe appealed the decision.

Atlanta attorneys said in court documents Roe didn't disclose his condition and warned he couldn't perform "essential functions" of an officer. The police department and city officials have refused to comment beyond court filings.

Roe said he was a criminal investigator with the city of Los Angeles, though he did not work with the police department. He discovered he had HIV in 1997 but said it didn't hinder his ability to perform his duties. He said his infection never came up with the city.

He moved to Atlanta to find a better job, and in January 2006 began the lengthy process to join the city's police force. He passed a written test, a psychological exam, computerized voice stress analysis and a background check. The roadblock came after a blood test during a physical revealed he had the virus that causes AIDS, his lawsuit said. The doctor did not do any further tests.

Roe said the physician, Dr. Alton Greene, told him Atlanta police had a policy of refusing to hire officers with the virus. Roe said the doctor's statement violates the Americans with Disabilities Act, which he said prevents employers from dismissing anyone because they have HIV.

The city said they do not systematically reject job applicants because of HIV, but instead they look at each individual on a case-by-case basis.

In Roe's case, the city said, the doctor recommended that he have "no physical contact or involvement with individuals."

Catherine Hanssens, executive director of the Center for HIV Law and Policy, said the Roe case centers on the "belief that, 30 years into the epidemic, HIV is easily transmitted and results in a death sentence when it is transmitted."

"And neither of those are remotely close to the truth," she said.

Nurses, paramedics and other first responders with HIV have faced similar challenges over the years by employers, said Hanssens, but she said legal fights in those professions don't often surface much anymore because decades of litigation and medical research shows those with HIV can work in higher-risk fields.

Scott Schoettes of Lambda Legal, the gay rights group that represents Roe, said the city will not be able to show that someone with HIV presents a public threat.

"And maybe other departments will realize that they should create a policy that explicitly says HIV should not disqualify you from getting a job," he said.

Police departments often don't have a policy about whether to hire an officer with HIV, and those that do are loath to advertise the decision to protect the privacy of their officers.

Darrel Stephens, the executive director of the Major Cities Chiefs Association, said his group has no guidelines for members on how to treat applicants with HIV. The Fraternal Order of Police also doesn't have a policy, but president Chuck Canterbury said his group argues that officers with the virus should be protected under the Americans with Disabilities Act.

Roe, who is in school studying criminal justice, said he's waging the legal battle because he wants to serve the city.

"Because of my desire to serve my community, I wouldn't want to be anywhere but out in the public," he said. "Making the streets safer for the underdog is one of the most rewarding things I can do."

___

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Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20120124/ap_on_re_us/us_police_hiv_lawsuit

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Tuesday, January 24, 2012

GE Capital Expands Construction Finance Business? ? World ...

GE Capital Expands Construction Finance Business?

In advance of a busy trade show season, GE Capital, Dealer Finance announced that it is doubling its sales force to support growing retail and wholesale demand for construction equipment financing.

GE Capital?s lending to the construction industry grew 36% in 2011 and the outlook for 2012 activity is strong, necessitating additional staff. ?The new hires will be spread across 10 regions in the U.S. to provide one-on-one assistance to our wholesale and retail customers when necessary,? said Kristi Webb, commercial leader of GE Capital, Dealer Finance. ?This enhanced coverage ensures that we?re ready to assist dealers with financing options ranging from straightforward same-day funding to complex structuring.?

This year is expected to bring modest growth and better overall conditions in the construction end markets. ?The non-residential building sector will benefit from gradually improving general economic conditions, corporate profits and employment numbers,? said Serena Tse, senior vice president and construction industry research manager at GE Capital. ?At the same time, the public sector is facing a difficult budget environment and the lack of a long-term transportation bill, while the residential sector will continue to be adversely affected by excess inventories.?

More information is available in a special update to GE Capital?s Construction Industry Research Monitor, available here: gelending.com/IndustryResearchMonitors/Construction_Update_1-12_.pdf.

To sign up for future issues of the Construction Industry Research Monitor, please click here: americas.gecapital.com/insights-ideas/industry-research-monitor.

At World of Concrete taking place this week in Las Vegas, GE Capital is the Gold Sponsor of the mobile application that gives attendees and exhibitors real-time information including alerts, an interactive floor plan, and Twitter and Facebook integration. Attendees who download the app also gain access to GE Capital?s ?Top 10 Tips for Smart Borrowers,? that suggests methods companies can use to increase the likelihood of success when seeking financing.

About GE Capital, Dealer Finance

GE Capital is America?s largest equipment leasing company. Through its Equipment Finance business, GE Capital provides commercial leases and loans, typically ranging from $5,000 to $25 million, to small and mid-sized manufacturers, dealers and end-business users to help drive cost efficiencies and top-line growth. Customizable financing solutions range from IT to construction, office imaging and medical equipment, and telecom, transportation, healthcare and more. For more information on dealer offerings from GE, visit dealerfinance.com.

GE Capital offers consumers and businesses around the globe an array of financial products and services. For more information, visit gecapital.com or follow company news via Twitter (@GECapital).

GE GE -0.58% works on things that matter. The best people and the best technologies taking on the toughest challenges. Finding solutions in energy, health and home, transportation and finance. Building, powering, moving and curing the world. Not just imagining. Doing. GE works. For more information, visit the company?s website at ge.com.

Source: http://www.worldleasingnews.com/news/ge-capital-expands-construction-finance-business%E2%80%8E/

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